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FtsZ

According to the World Health Organization (WHO), 2 million people die from Tuberculosis each year. The WHO's Global Tuberculosis Control report for 2005, says that the prevalence of the disease has dropped by more than 20% since 1990, however the battle against tuberculosis is far from over. The WHO recently rated the rate of the disease in Africa as having reached alarming proportions with a growing number of TB cases and deaths linked to HIV. (Source: WHO Stop TB Department)

Tuberculosis (TB) is a disease caused by bacteria called Mycobacterium tuberculosis. The bacteria usually attack the lungs but, can attack any part of the body such as the kidney, spine, and brain. If not treated properly, TB disease can be fatal. TB is spread through the air from one person to another when a person with active TB disease of the lungs or throat coughs or sneezes. People nearby may breathe in these bacteria and become infected.

FtsZ is a very promising target for new antimicrobial drugs because of its central role in bacterial cell division. FtsZ, a tubulin-like GTPase, plays an essential role in bacterial cell division, and its homologs are present in almost all eubacteria and archaea.